Filippo Giancotti MD PhD
 

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Filippo G. Giancotti, MD, PhD
Herbert and Florence Irving Professor of Basic Cancer Science
Professor of Genetics and Development
Director of the Cancer Metastasis Initiative
Herbert Irving Comprehensive Cancer Center
Vagelos College of Physicians and Surgeons
Columbia University

About

Drivers of oncogenesis highjack the regulatory circuitry that governs the social behavior of tissue progenitor cells, enabling their transformed derivatives to spread throughout the body and colonize vital organs. In many patients, definitive treatment of the primary cancer is followed years later by metastatic relapse. During this lag time, tumor cells that have disseminated throughout the body prior to diagnosis remain in a non-proliferative state. We study the molecular mechanisms that enable dormant metastatic cells to survive the stress of a foreign microenvironment, evade the immune system, and eventually undergo reactivation. We study these biological processes not only because they are complex and fascinating, but also because understanding their molecular basis will lead to the development of novel and more effective cancer therapies.  

Latest Publications

Han, H., Wang, Y., Curto, J., Gurrapu, S., Laudato, S., Rumandla, A., Chakraborty, G., Wang, X., Chen, H., Jiang, Y., et al. (2022). Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis.
Cell Reports 39,110595. https://doi.org/10.1016/j.celrep.2022.110595. (In press, April 5th, 2022) 

Feature Publications

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At the Herbert Irving Comprehensive Cancer Center (HICCC), we believe that our discoveries here, will end cancer everywhere. When you give to the HICCC, you are making a difference in the lives of cancer patients. Your support accelerates the discoveries made in our lab into the innovative cancer care of tomorrow. Please contact Office of Development, at 212-304-7206 or djd2152@cumc.columbia.edu for further information about how to contribute, gift planning, and other funding opportunities at CUIMC.