Yan Wang, Ph. D.
Associate Research Scientist
Yan Wang is an Associate research scientist. Yan received his Ph.D. in Biochemistry and Molecular Biology from Dr. Guohong Li Lab, Institute of Biophysics, Chinese Academy of Sciences, China in 2014. During his Ph.D. studies, he focused on the role of histone variants in chromatin folding, epigenetic landscape and gene expression. He elucidated the coordination between H2A.Z and H3.3, which plays an important role in the transcriptional regulation of developmental genes through modulating chromatin structure and PRC2-dependent H3K27me3 deposition in mouse embryonic stem cells. (Wang et al. BMC Biology. 2018; Wang et al. Nucleus. 2014; Wang et al. Genes Dev. 2013). In our laboratory, Yan is focused on epigenetic reprogramming in prostate cancer metastasis and drug resistance. He found that AR inhibition induced a cascade of chromatin opening which led to the transition of massive enhancer sites from inactive to the poised or active state (Han and Wang et al. Biorxiv. 2021). His current studies focus on identifying the signaling pathways associated with the metastatic tumor specific enhancers and their mechanisms in tumor progression and drug resistance in prostate cancer cells.